منابع مشابه
Evidence for a Transport Carrier of Nitrogen Mustard in Nitrogen Mustard-sensitive and -resistant L5178Y Lymphoblasts1
inhibited by ouabain and 2,4-dinitrophenol. These findings suggest that transport of HN2 is carrier-mediated and is an active process. The Km for resistant cells was higher than that of sensitive cells, suggesting a decreased affinity of the trans port carrier for drug. The Vmax of resistant cells was lower than that of sensitive lymphoblasts, suggesting decreased trans port capacity in resista...
متن کاملHematologic effects of regional nitrogen mustard therapy.
By JEANNE C. BATEMAN,* M.D., CALVIN T. KLOPP, M.D., and J. KEITH CROMER, M.D. M ETHYL his (beta-chloroethyl) amine hydrochloride (referred to hereafter as HN2) has been established as an effective agent in the palliative therapy of certain malignant diseases, includ!ing Hodgkin’s dhsease, lymphosarcoma, mycosis fungoides, chronic leukemia, polycythemia and some cases of inoperable carcinoma of ...
متن کاملTreatment of bronchogenic carcinoma with nitrogen mustard.
There have been numerous reports as to the clinical results obtained with the chloroethylamines (nitrogen mustards) In the treatment of Hodgkin’s disease, lymphosarcoma and leukemia.’-11’9 There has been a paucity of reported clinical trials in regard to the treatment of bronchogenic carcinoma with nitrogen mustard despite the fact that a few cases of carcinoma of the lung treated with nitrogen...
متن کاملNitrogen mustard inhibition of azo dye carcinogenesis.
Cellular growth and development may be al tered appreciably by administration of the nitro gen mustards. The chemotherapeutic value of these compounds in the treatment of leukemia and other neoplasms has been well established (5). In addition, the studies reported by Auerbach, Ta turn, Karnofsky, and others have indicated that these agents are mutagenic for Drosophila (1, @), Neurospora (@1), b...
متن کاملThe Reactions of Chloroquine Mustard (CQM) and Nitrogen Mustard (HN2) with Ehrlich Cells*t
By incubating Ehrlich cells with isotopically labeled nitrogen mustards the relation between the extent of alkylation of cell constituents and the reduction of growth potential can be studied. Data obtained by such studies show that both CQM and HN2 react with a wide variety of cell constituents. Of the macromolecular constituents, the proteins undergo the greatest amount of alkylation, but the...
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ژورنال
عنوان ژورنال: Postgraduate Medical Journal
سال: 1948
ISSN: 0032-5473
DOI: 10.1136/pgmj.24.272.307